| Protein Name: | Nitric-oxide synthase (P29475) |
|---|---|
| Gene Name: | DRD2 |
| Description: | Nitric-oxide synthase, brain (EC 1 14 13 39) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Constitutive NOS) (NC-NOS) (bNOS) |
| PDB ID: | 4D1N |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| cytokines interleukin-1beta (IL-1beta) | Apoptosis | Induction by the cytokines interleukin-1beta (IL-1beta)increased production of nitric oxide (NO) after induction of the cytokine-inducible isoform of nitric oxide synthase (iNOS or NOS2) in cardiac myocytes and other parenchymal cells within the heart may in addition to contributing to myocyte contractile dysfunction also contribute to the induction of programmed cell death (apoptosis) [ ADR Type 5 ] | Parsing the effects of nitric oxide, S-nitrosothiols, and peroxynitrite on inducible nitric oxide synthase-dependent cardiac myocyte apoptosis |
| cytokines interleukin-1beta (IL-1beta) | Myocyte Contractile Dysfunction | Induction by the cytokines interleukin-1beta (IL-1beta)increased production of nitric oxide (NO) after induction of the cytokine-inducible isoform of nitric oxide synthase (iNOS or NOS2) in cardiac myocytes and other parenchymal cells within the heart may in addition to contributing to myocyte contractile dysfunction also contribute to the induction of programmed cell death (apoptosis) [ ADR Type 5 ] | Parsing the effects of nitric oxide, S-nitrosothiols, and peroxynitrite on inducible nitric oxide synthase-dependent cardiac myocyte apoptosis |
This panel provides information on drug category
| Toxicity | Source |
|---|