InAADR

Protein Information

Protein Name: Prostaglandin G/H synthase 1 precursor (P23219)
Gene Name: PTGS1
Description:
PDB ID:
Protein Family: PF03098, PS50026
Protein Category: Enzyme

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Clemastine Sleep Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets
Nafazatrom Inactivation Of Phs Oxygenated derivative of PB@ rather than the parent compound@ which is responsible for the inactivation of PHS and prostacyclin synthase@blocks the effects of the PB and H2O2 treatment. [ ADR Type 1 ] Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone Requirement for peroxidative metabolism

This panel provides information on drug category

Toxicity Source
Abdominal Pain Large-scale prediction and testing of drug activity on side-effect targets
Aplastic Anaemia Large-scale prediction and testing of drug activity on side-effect targets
Asthma Large-scale prediction and testing of drug activity on side-effect targets
Dyspepsia Large-scale prediction and testing of drug activity on side-effect targets
Erythema Multiforme Large-scale prediction and testing of drug activity on side-effect targets
Gastrointestinal Haemorrhage Large-scale prediction and testing of drug activity on side-effect targets
Haematuria Large-scale prediction and testing of drug activity on side-effect targets
Haemorrhagic Diathesis Large-scale prediction and testing of drug activity on side-effect targets
Hepatitis Large-scale prediction and testing of drug activity on side-effect targets
Nephropathy Large-scale prediction and testing of drug activity on side-effect targets
Oedema Large-scale prediction and testing of drug activity on side-effect targets
Peptic Ulcer Large-scale prediction and testing of drug activity on side-effect targets
Pruritus Large-scale prediction and testing of drug activity on side-effect targets
Rash Large-scale prediction and testing of drug activity on side-effect targets
Renal Failure Large-scale prediction and testing of drug activity on side-effect targets
Renal Tubular Disorder Large-scale prediction and testing of drug activity on side-effect targets
Thrombocytopenia Large-scale prediction and testing of drug activity on side-effect targets
Tinnitus Large-scale prediction and testing of drug activity on side-effect targets
Toxic Epidermal Necrolysis Large-scale prediction and testing of drug activity on side-effect targets
Ulceration Nitric oxide: potential role for reducing gastro-enteropathy

InAADR: Drug-Protein-ADRs database