| Protein Name: | S-adenosylmethionine decarboxylase (P17707) |
|---|---|
| Gene Name: | AMD1 |
| Description: | S-adenosylmethionine decarboxylase proenzyme (EC 4 1 1 50) (AdoMetDC) (SamDC) [Contains: S-adenosylmethionine decarboxylase alpha chain; S- adenosylmethionine decarboxylase beta chain] |
| PDB ID: | 1I72 |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Chlorpromazine | Stimulated Ornithine Decarboxylase Activity | Single dose of chlorpromazine stimulated ornithine decarboxylase activity 7-fold and decreased S-adenosylmethionine decarboxylase activity to 50% from the control level [ ADR Type 1 ] | The inverse changes of mouse brain ornithine and S-adenosylmethionine decarboxylase activities by chlorpromazine and imipramine Dependence of ornithine decarboxylase induction |
| Ifosfamide | Stimulated Ornithine Decarboxylase Activity | Single dose of imipramine stimulated ornithine decarboxylase activity 7-fold and decreased S-adenosylmethionine decarboxylase activity to 50% from the control level [ ADR Type 1 ] | The inverse changes of mouse brain ornithine and S-adenosylmethionine decarboxylase activities by chlorpromazine and imipramine Dependence of ornithine decarboxylase induction |
This panel provides information on drug category
| Toxicity | Source |
|---|