| Protein Name: | Aspartate aminotransferase cytoplasmic (P17174) |
|---|---|
| Gene Name: | GOT1 |
| Description: | Aspartate aminotransferase, cytoplasmic (EC 2 6 1 1) (Transaminase A) (Glutamate oxaloacetate transaminase 1) |
| PDB ID: | 3II0 |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| ionotropic | Neurotoxicity | GABA neurotoxicity persisted in the presence of either the antaGOnists of ionotropic and metabotropic glutamate receptors or glutamate pyruvate transaminase@ which induces an immediate catabolism of glutamate [ ADR Type 2 ] | GABA is toxic for mouse striatal neurones through a transporter-mediated process |
| Methotrexate | Increase In The Death Rate | If methotrexate is applied@ there is an increase in the death rate@ as well as in glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) activities. [ ADR Type 2 ] | Nicotinamide and methionine reduce the liver toxic effect of methotrexate |
This panel provides information on drug category
| Toxicity | Source |
|---|