| Protein Name: | Cytochrome P450 (P15538) |
|---|---|
| Gene Name: | CYP11B1 |
| Description: | Cytochrome P450 11B1, mitochondrial precursor (EC 114154) (CYPXIB1) (P450C11) (P-450c11) (Steroid 11-beta-hydroxylase) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Renal Functional Changes | APAP-induced renal functional changes(elevation in blood urea nitrogen and reduction in the accumulation of p-aminohippurate by renal cortical slices) also correlated with strain-dependent histopathological changes. Such strain differences have been attributed to differences in renal P-450 activation of APAP or the deacetylation of APAP to the nephrotoxic metabolite@ p-aminophenol (PAP). [ ADR Type 1 ] | Acetaminophen nephrotoxicity in the rat I Strain differences in nephrotoxicity and metabolism |
This panel provides information on drug category
| Toxicity | Source |
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