| Protein Name: | Hepatocyte growth factor (P14210) |
|---|---|
| Gene Name: | HGF |
| Description: | Hepatocyte growth factor precursor (Scatter factor) (SF) (Hepatopoeitin A) [Contains: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain] |
| PDB ID: | 1BHT |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cytarabine | Cytotoxicity | Stimulation of clonogenic acute myeloid leukemia (AML) cells by hematopoietic growth factors (HGF) is capable of enhancing cytosine-arabinoside (Ara-C) cytotoxicity in vitro. [ ADR Type 1 ] | Hematopoietic growth factor stimulation and cytarabine cytotoxicity in vitro: effects in untreated and relapsed or primary refractory acute myeloid leukemia cells |
| Ribavirin | Affect Hepatic Functions | [3H]-Thymidine incorporation was suppressed both in hepatocyte growth factor-stimulated human hepatocytes and in epidermal growth factor (EGF)-stimulated rat hepatocytes in the presence of ribavirin@demonstrating that ribavirin at concentrations close to those found in plasma of treated patients can directly affect hepatic functions in vitro. [ ADR Type 1 ] | Ribavirin inhibits protein synthesis and cell proliferation induced by mitogenic factors in primary human and rat hepatocytes |
This panel provides information on drug category
| Toxicity | Source |
|---|