| Protein Name: | Glial fibrillary acidic protein (P14136) |
|---|---|
| Gene Name: | Not Available |
| Description: | Phospholipase A2, spermatozoa (EC 3 1 1 4) (Phosphatidylcholine 2- acylhydrolase) (Fragment) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Neomycin | Cell Loss And Degeneration | Neomycin treatment also INCREASED GFAP and OX-6 immunostaining@ as well as cell loss and degeneration in the lesioned area@while a higher dose of neomycin (50 nmol) causing more DRAMATIC cell loss and degeneration with extensive striatal GFAP and OX-6 immunoreactivity [ ADR Type 5 ] | Aminoglycoside neurotoxicity involves NMDA receptor activation |
| Penicillin v | Depression | Induction of cortical spreading depression with potassium chloride upregulates levels of messenger RNA for Glial fibrillary acidic protein in cortex and hippocampus [ ADR Type 1 ] | Induction of cortical spreading depression with potassium chloride upregulates levels of messenger RNA for glial fibrillary acidic protein in cortex and hippocampus: inhibition |
This panel provides information on drug category
| Toxicity | Source |
|---|---|
| Depression | Analysis of c-Fos and glial fibrillary acidic protein (GFAP) expression following topical application of potassium chloride (KCl) to the brain surface |