| Protein Name: | Glycogen synthase (P13807) |
|---|---|
| Gene Name: | GYS1 |
| Description: | Glycogen [starch] synthase, muscle (EC 2 4 1 11) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Glipizide | Suppression Of Hepatic Glucose Production | Glucose-induced suppression of hepatic glucose production was@ however@ more pronounced during GZ treatment ;GZ tends to normalize the activity of glycogen synthase and increases the content of GLUT 4 protein in skeletal muscle. [ ADR Type 1 ] | Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity |
| Piroxicam | Impairment Into Glycogen Metabolism | A decrease in the glycogen synthase in the active I form was time-dependent on piroxicam treatment The impairment into glycogen metabolism produced by piroxicam administration suggests liver becomes unable to maintain glucose homeostasis [ ADR Type 2 3 ] | Hepatic glycogen depletion in fed female rats induced by piroxicam |
This panel provides information on drug category
| Toxicity | Source |
|---|