| Protein Name: | Ornithine decarboxylase (P11926) |
|---|---|
| Gene Name: | ODC1 |
| Description: | Ornithine decarboxylase (EC 4 1 1 17) (ODC) |
| PDB ID: | 1D7K |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Hepatotoxicity | Liver ornithine decarboxylase (ODC) activity@ which reflects the earliest phases of cell multiplication@During the next 12 hours@decreased by 60% to 70% and cellular necrosis became evident@and reached a peak at 24 to 36 hours.So organelles may play a critical role in acetaminophen hepatotoxicity. [ ADR Type 2 ] | Acetaminophen liver injury: sequential changes in two biochemical indices of regeneration and their relationship to histologic alterations |
| Chlorpromazine | Stimulated Ornithine Decarboxylase Activity | Single dose of chlorpromazine stimulated ornithine decarboxylase activity 7-fold and decreased S-adenosylmethionine decarboxylase activity to 50% from the control level [ ADR Type 1 ] | The inverse changes of mouse brain ornithine and S-adenosylmethionine decarboxylase activities by chlorpromazine and imipramine Dependence of ornithine decarboxylase induction |
| Dexamethasone | Peptic Ulcers | The activity of ornithine decarboxylase (ODC) INCREASED at 4 h@accelerated turnover of histamine in oxyntic mucosa may be an important factor in the pathogenesis of peptic ulcers [ ADR Type 1 ] | Effects of dexamethasone on the activity of histidine decarboxylase, ornithine decarboxylase, and dopa decarboxylase in rat oxyntic mucosa |
| Ifosfamide | Stimulated Ornithine Decarboxylase Activity | Single dose of imipramine stimulated ornithine decarboxylase activity 7-fold and decreased S-adenosylmethionine decarboxylase activity to 50% from the control level [ ADR Type 1 ] | The inverse changes of mouse brain ornithine and S-adenosylmethionine decarboxylase activities by chlorpromazine and imipramine Dependence of ornithine decarboxylase induction |
This panel provides information on drug category
| Toxicity | Source |
|---|