| Protein Name: | CYP2A6 (P11509) |
|---|---|
| Gene Name: | CYP2A6 |
| Description: | Cytochrome P450 2A6 (EC 1 14 14 1) (CYPIIA6) (Coumarin 7-hydroxylase) (P450 IIA3) (CYP2A3) (P450(I)) |
| PDB ID: | 1Z10 |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Halothane | Hepatotoxicity | Both P450 2E1 and P450 2A6 participate in human halothane metabolism@ and that P450 2E1 is the predominant catalytic isoform | |
| Valproic Acid | Hepatotoxicity | CYP3A4@ the isoform usually associated with induction by anticonvulsants cannot be responsible for the enhanced 4-ene-VPA formation that occurs during polytherapy. Instead@ enhanced activity in vivo likely results from induction of CYP2A6. [ ADR Type 2 ] | Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans |
This panel provides information on drug category
| Toxicity | Source |
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