| Protein Name: | glucose-regulated protein (P11021) |
|---|---|
| Gene Name: | HSPA5 |
| Description: | 78 kDa glucose-regulated protein precursor (GRP 78) (Immunoglobulin heavy chain-binding protein) (BiP) (Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78) |
| PDB ID: | 3IUC |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Lidocaine | Intestinal Disorder | The acquisition of normal trafficking and function appears to utilize several cycles of anterograde and retrograde steps between the endoplasmic reticulum and the GOlgi implicating the molecular chaperones calnexin and heavy chain-binding protein implicate a temperature-sensitive mutation in an intestinal enzyme deficiency or an intestinal disorder [ ADR Type 3 ] | A glutamine to proline exchange at amino acid residue 1098 in sucrase causes a temperature-sensitive arrest of sucrase-isomaltase in the endoplasmic reticulum and cis-Golgi |
| Zalcitabine | Cardiotoxicity | An activation of the nuclear poly-(ADP-ribose) polymerase and an increase in the mono-ADP-ribosylation of glucose-regulated protein and desmin were observed in the cardiac tissue from ddC-treated animals@which suggests that the short term cardiotoxicity of ddC is partially based on ROS-mediated signalling. [ ADR Type 2 ] | Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions |
This panel provides information on drug category
| Toxicity | Source |
|---|