InAADR

Protein Information

Protein Name: Interleukin-8 (P10145)
Gene Name: IL8
Description: Interleukin-8 precursor (IL-8) (CXCL8) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (T-cell chemotactic factor) (Neutrophil- activating protein 1) (NAP-1) (Protein 3-10C) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil
PDB ID: 1ICW
Protein Family:
Protein Category: Secreted Protein

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Epinephrine Inflammation Epinephrine-induced enhancement of IL-8 production@which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation [ ADR Type 5 ] Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone
Hydrocortisone Inflammation Hydrocortisone dose-dependently inhibited LPS-induced IL-8 production@which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation [ ADR Type 1 ] Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone
Ibritumomab Pathogenesis Of Side-Effects Infusion of rituximab induced rapid complement activation@ preceding the release of TNF-alpha@ IL-6 and IL-8@which is correlated with pathogenesis of side-effects [ ADR Type 5 ] Complement activation plays a key role in the side-effects of rituximab treatment
Nicotine Ulcerative Colitis Transdermal nicotine decreases mucosal IL-8 expression@which lead to ulcerative colitis [ ADR Type 5 ] Transdermal nicotine decreases mucosal IL-8 expression but has no effect on mucin gene expression in ulcerative colitis Inflamm Bowel Dis 1

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database