| Protein Name: | Poly [ADP-ribose] polymerase (P09874) |
|---|---|
| Gene Name: | PARP1 |
| Description: | Poly [ADP-ribose] polymerase 1 (EC 24230) (PARP-1) (ADPRT) (NAD(+) ADP-ribosyltransferase 1) (Poly[ADP-ribose] synthetase 1) |
| PDB ID: | 1UK0 |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Zalcitabine | Cardiotoxicity | An activation of the nuclear poly-(ADP-ribose) polymerase and an increase in the mono-ADP-ribosylation of glucose-regulated protein and desmin were observed in the cardiac tissue from ddC-treated animals@which suggests that the short term cardiotoxicity of ddC is partially based on ROS-mediated signalling. [ ADR Type 2 ] | Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions |
This panel provides information on drug category
| Toxicity | Source |
|---|