| Protein Name: | phosphatidylinositol-specific phospholipase C (P09194) |
|---|---|
| Gene Name: | Not Available |
| Description: | Variant-surface-glycoprotein phospholipase C (EC 4 6 1 14) (VSG lipase) (Glycosylphosphatidylinositol-specific phospholipase C) (GPI- PLC) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Gentamicin | Nephrotoxicity | Kidney cortex cytosolic PI-PLC activity is also inhibited by gentamicin@suggesting gentamicin-induced modulation of BBM PI-PLC may be an important factor in ensuing nephrotoxicity. [ ADR Type 1 ] | Effects of aminoglycosides on proximal tubule brush border membrane phosphatidylinositol-specific phospholipase |
| Simvastatin | Nephrotoxicity | Comparative inhibition of phosphatidylinositol-specific phospholipase C (PI-PLC) by other aminoglycosides (at 1-2 mM concentrations) approximates their known nephrotoxic potential [ ADR Type 1 ] | Effects of aminoglycosides on proximal tubule brush border membrane phosphatidylinositol-specific phospholipase |
This panel provides information on drug category
| Toxicity | Source |
|---|