InAADR

Protein Information

Protein Name: Alpha-2A adrenergic receptor (P08913)
Gene Name: ADRA2A
Description:
PDB ID: 1HLL
Protein Family: PF00001, PS00237
Protein Category: Membrane Receptors

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Acetaminophen Hepatic Injury Acetaminophen is potentiated by alpha(1)-adrenoreceptor aGOnists@creating the potential for increased susceptibility to hepatic injury [ ADR Type 2 ] Adrenergic modulation of hepatotoxicity
Brimonidine Platelet Aggregation Alpha 2-Adrenoceptor(epinephrine and UK 14304)-mediated platelet aggregation could represent a better marker than inhibition of adenylate cyclase to assess functional changes of the receptor in depression [ ADR Type 1 ] Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression Effect of long-term cyclic antidepressant drug treatment
Carbon tetrachloride Hepatic Injury Potentiation of carbon tetrachloride hepatotoxicity appears to be mediated by alpha(2)-adrenoceptor stimulation@creating the potential for increased susceptibility to hepatic injury [ ADR Type 2 ] Adrenergic modulation of hepatotoxicity
Epinephrine Platelet Aggregation Alpha 2-Adrenoceptor(epinephrine and UK 14304)-mediated platelet aggregation could represent a better marker than inhibition of adenylate cyclase to assess functional changes of the receptor in depression. [ ADR Type 1 ] Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression Effect of long-term cyclic antidepressant drug treatment
Ifosfamide Anxiety Alpha(2A)-AR knock-out mice appear more anxious than wild-type C57 Bl/6 mice in the rearing and light-dark models of anxiety after injection stress [ ADR Type 3 ] Alpha-adrenergic receptors mediate imipramine/alarm substance-induced reaction in rats
Ifosfamide Insensitive To The Antidepressant Effects The genetic knock-out of the alpha(2A)-AR makes mice LESS ACTIVE in a modified version of Porsolt#s forced swim test and insensitive to the antidepressant effects of the tricyclic drug imipramine in this paradigm [ ADR Type 3 ] Alpha-adrenergic receptors mediate imipramine/alarm substance-induced reaction in rats

This panel provides information on drug category

Toxicity Source
Bradycardia Large-scale prediction and testing of drug activity on side-effect targets
Cerebral Haemorrhage Large-scale prediction and testing of drug activity on side-effect targets
Depressed Level Of Consciousness Large-scale prediction and testing of drug activity on side-effect targets
Dyskinesia Large-scale prediction and testing of drug activity on side-effect targets
Ejaculation Disorder Large-scale prediction and testing of drug activity on side-effect targets
Fear Large-scale prediction and testing of drug activity on side-effect targets
Gangrene Large-scale prediction and testing of drug activity on side-effect targets
Gestational Hypertension Large-scale prediction and testing of drug activity on side-effect targets
Hallucination Large-scale prediction and testing of drug activity on side-effect targets
Intranasal Paraesthesia Large-scale prediction and testing of drug activity on side-effect targets
Nasal Congestion Large-scale prediction and testing of drug activity on side-effect targets
Nasal Discomfort Large-scale prediction and testing of drug activity on side-effect targets
Nasal Dryness Large-scale prediction and testing of drug activity on side-effect targets
Nervous System Disorder Large-scale prediction and testing of drug activity on side-effect targets
Neurosis Large-scale prediction and testing of drug activity on side-effect targets
Orthostatic Hypotension Large-scale prediction and testing of drug activity on side-effect targets
Pallor Large-scale prediction and testing of drug activity on side-effect targets
Palpitations Large-scale prediction and testing of drug activity on side-effect targets
Priapism Large-scale prediction and testing of drug activity on side-effect targets
Respiration Abnormal Large-scale prediction and testing of drug activity on side-effect targets
Sneezing Large-scale prediction and testing of drug activity on side-effect targets
Somnolence Large-scale prediction and testing of drug activity on side-effect targets
Urinary Incontinence Large-scale prediction and testing of drug activity on side-effect targets
Vasoconstriction Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database