InAADR: Drug-Protein-ADRs database

InAADR

Enter Protein Name or Uniprot ID:

Protein Information

Protein Name:	Muscarinic acetylcholine receptor M2 (P08172)
Gene Name:	CHRM2
Description:
PDB ID:	1LUB
Protein Family:	PF00001, PS00237
Protein Category:	Membrane Receptors

Drug-Protein Interaction
Adverse Drug Reactions

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs	Toxicity	Mechanism	Reference
Carbachol	Bradycardia	Carbamylcholine produced bradycardia through the low-affinity state of the M(2) receptor [ ADR Type 1 ]	Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor aGOnists sabcomeline and xanomeline
Diethylstilbestrol	Rash	Not Available	Large-scale prediction and testing of drug activity on side-effect targets
Dihydrotachysterol	Hypercalcaemia	Not Available	Large-scale prediction and testing of drug activity on side-effect targets
Medroxyprogesterone	Adrenal Disorder	Not Available	Large-scale prediction and testing of drug activity on side-effect targets
sabcomeline	Bradycardia	Sabcomeline produced bradycardia through the low-affinity state of the M(2) receptor. [ ADR Type 1 ]	Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor aGOnists sabcomeline and xanomeline
xanomeline	Bradycardia	Xanomeline produced bradycardia through the low-affinity state of the M(2) receptor [ ADR Type 1 ]	Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor aGOnists sabcomeline and xanomeline

This panel provides information on drug category

Toxicity	Source
Anticholinergic Syndrome	Large-scale prediction and testing of drug activity on side-effect targets
Constipation	Large-scale prediction and testing of drug activity on side-effect targets
Cycloplegia	Large-scale prediction and testing of drug activity on side-effect targets
Diabetic Eye Disease	Large-scale prediction and testing of drug activity on side-effect targets
Dry Mouth	Large-scale prediction and testing of drug activity on side-effect targets
Dry Skin	Large-scale prediction and testing of drug activity on side-effect targets
Extrapyramidal Disorder	Large-scale prediction and testing of drug activity on side-effect targets
Gastric Hypomotility	Large-scale prediction and testing of drug activity on side-effect targets
Hyperpyrexia	Large-scale prediction and testing of drug activity on side-effect targets
Intraocular Pressure Increased	Large-scale prediction and testing of drug activity on side-effect targets
Mydriasis	Large-scale prediction and testing of drug activity on side-effect targets
Salivary Hypersecretion	Large-scale prediction and testing of drug activity on side-effect targets
Tachycardia	Large-scale prediction and testing of drug activity on side-effect targets
Urinary Incontinence	Large-scale prediction and testing of drug activity on side-effect targets
Urinary Retention	Large-scale prediction and testing of drug activity on side-effect targets
Vision Blurred	Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database