| Protein Name: | Heat shock protein HSP 90 (P07900) |
|---|---|
| Gene Name: | HSP90AA1 |
| Description: | Heat shock protein HSP 90-alpha (HSP 86) |
| PDB ID: | 1BYQ |
| Protein Family: | |
| Protein Category: | Cytosolic Protein |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| LAQ824 | Apoptosis | Depleted the mRNA and protein expression of BCR-ABL in human chronic myeloid leukemia blast crisis (CML-BC) cells;induced the expression of the cell cycle-dependent kinase inhibitors p21 and p27 and caused cell cycle G(1)-phase accumulation and apoptosis of CML-BC cells. [ ADR Type 2 ] | Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis |
This panel provides information on drug category
| Toxicity | Source |
|---|