InAADR

Protein Information

Protein Name: Glutathione peroxidase 1 (P07203)
Gene Name: GPX1
Description: Glutathione peroxidase 1 (EC 1 11 1 9) (GSHPx-1) (GPx-1) (Cellular glutathione peroxidase)
PDB ID: 2F8A
Protein Family:
Protein Category: Enzyme

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Cephaloridine Impair Antioxidant Status Selenium deficiency impaired antioxidant status and enhanced cephaloridine-induced injury [ ADR Type 3 ] Cephaloridine nephrotoxicity is potentiated by selenium deficiency but not copper deficiency in rats
Cephaloridine Nephrotoxicity Selenium deficiency potentiated cephaloridine nephrotoxicity [ ADR Type 3 ] Cephaloridine nephrotoxicity is potentiated by selenium deficiency but not copper deficiency in rats
Cisplatin Nephrotoxicity Treatment of rats with cisplatin or with cisplatin after chronic pre-exposure to cadmium induced a decrease in kidney cytochrome P-450 and glutathione levels@ and in glutathione peroxidase and reductase activities. And cadmium nephrotoxicity was characterized by tubular proximal damage with mitochondrial and lysosomal changes and a widespread vesiculation of tubular cells. [ ADR Type 1 ] Cisplatin nephrotoxicity in cadmium-pretreated rats Enzymatic, functional and morphological studies
Cisplatin Ototoxicity Cisplatin ototoxicity is related to depletion of glutathione and glutathione peroxidase in the cochlea. [ ADR Type 2 ] Application of antioxidants and other agents to prevent cisplatin ototoxicity
Cyclophosphamide Lung Toxicity Significant reductions (P less than 0 005) in G6PD@ GSH-R@ and GSH-P activities occurred on days 1-5@indicating that Cyclophosphamide causes lung toxicity [ ADR Type 2 ] Cyclophosphamide-induced depression of the antioxidant defense mechanisms of the lung
Diethylstilbestrol Unscheduled Dna Synthesis (Uds) DES can potentially form phenoxyradical intermediates by a peroxidase-mediated reaction@which leads to unscheduled DNA synthesis (UDS) in Syrian hamster embryo cells. [ ADR Type 2 ] Dependence on exogenous metabolic activation for induction of unscheduled DNA synthesis in Syrian hamster embryo cells by diethylstilbestrol and related compounds

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database