| Protein Name: | Beta-hexosaminidase (P06865) |
|---|---|
| Gene Name: | HEXA |
| Description: | Beta-hexosaminidase alpha chain precursor (EC 3 2 1 52) (N-acetyl- beta-glucosaminidase) (Beta-N-acetylhexosaminidase) (Hexosaminidase A) |
| PDB ID: | 1QBC |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cisplatin | Nephrotoxicity | Cisplatin increased urinary excretion of LDH (six-fold)@ GGT (twofold)@ and NAG (twofold); CI-973 and carboplatin increased GGT excretion (approximately twofold)@which produced marked nephrotoxicity as determined by biochemical@ functional@ and histopathologic endpoints [ ADR Type 2 ] | Comparative nephrotoxicity of a novel platinum compound, cisplatin, and carboplatin in male |
| doxorubicin hydrochloride nephrosis (AN) | Renal Tubular Injury | The urinary excretion of lysozyme and N-acetyl-glucosaminidase@ markers of renal tubular injury@ were significantly increased after 7 or 14 days in rats with doxorubicin hydrochloride nephrosis (AN) [ ADR Type 2 ] | Amelioration of glomerular injury in doxorubicin hydrochloride nephrosis by dimethylthiourea |
This panel provides information on drug category
| Toxicity | Source |
|---|