| Protein Name: | Alkaline phosphatase (P05186) |
|---|---|
| Gene Name: | ALPL |
| Description: | Alkaline phosphatase, tissue-nonspecific isozyme precursor (EC 3131) (AP-TNAP) (Liver/bone/kidney isozyme) (TNSALP) |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Hepatotoxicity | Elevation of alkaline phosphatase leads to severe hepatotoxicity in a patient receiving both acetaminophen and zidovudine. [ ADR Type 4 ] | Acetaminophen hepatotoxicity augmented by zidovudine |
| Furazolidone | Loss Of Appetite | Increase in serum aspartate aminotransferase (AST)@ Alanine aminotransferase (ALT) and alkaline phosphatase and a decrease in serum total protein@which leads to a loss of appetite causing emaciation followed by nervous disturbances (compulsive movements and circling). [ ADR Type 1 ] | Toxicological and biological studies on Japanese quails fed graded levels of furazolidone |
| Phenytoin | Hyperbilirubinemia | Increased activities of Alanine aminotransferase@ alkaline phosphatase (AP)@ and gamma-glutamyltransferase@leading to clinical jaundice and developed hyperbilirubinemia@ delayed sulfobromophthalein excretion@ and increased conjugated bile acid concentrations. [ ADR Type 1 ] | Comparison of rosaramicin and erythromycin stearate for treatment of cervical infection with Chlamydia trachomatis |
| Primidone | Hyperbilirubinemia | Increased activities of Alanine aminotransferase@ alkaline phosphatase (AP)@ and gamma-glutamyltransferase@leading to clinical jaundice and developed hyperbilirubinemia@ delayed sulfobromophthalein excretion@ and increased conjugated bile acid concentrations. [ ADR Type 1 ] | Comparison of rosaramicin and erythromycin stearate for treatment of cervical infection with Chlamydia trachomatis |
This panel provides information on drug category
| Toxicity | Source |
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