This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs |
Toxicity |
Mechanism |
Reference |
|---|
| Dehydrated Alcohol | Impair Liver Regeneration | Ethanol treatment resulted in 30 to 50% reductions in the expression levels of two important insulin-responsive genes: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and proliferating cell nuclear antigen (PCNA),suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression,which leads to chronic ethanol toxicity impairs liver regeneration, inhibits DNA synthesis, and mutes cellular responses to growth factor stimulation [ ADR Type 1 ] | Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells
|
| Dehydrated Alcohol | Inhibit Dna Synthesis | Ethanol treatment resulted in 30 to 50% reductions in the expression levels of two important insulin-responsive genes: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and proliferating cell nuclear antigen (PCNA),suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression,which leads to chronic ethanol toxicity impairs liver regeneration, inhibits DNA synthesis, and mutes cellular responses to growth factor stimulation [ ADR Type 1 ] | Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells
|
| Dehydrated Alcohol | Mute Cellular Responses To Growth Factor Stimulation | Ethanol treatment resulted in 30 to 50% reductions in the expression levels of two important insulin-responsive genes: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and proliferating cell nuclear antigen (PCNA),suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression,which leads to chronic ethanol toxicity impairs liver regeneration, inhibits DNA synthesis, and mutes cellular responses to growth factor stimulation [ ADR Type 1 ] | Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells
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This panel provides information on drug category