InAADR

Protein Information

Protein Name: HLA class II histocompatibility antigen DRB1-1 (P04229)
Gene Name: HLA-DRB1
Description: HLA class II histocompatibility antigen, DRB1-1 beta chain precursor (MHC class I antigen DRB1*1)(DR-1) (DR1)
PDB ID: 1AQD
Protein Family:
Protein Category: Surface Antigen

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Methimazole Autoimmune Syndrome Allele specificity of structural requirement for peptides bound to HLA-DRB1 0405 and -DRB1 0406 complexes,which implicates for the HLA-associateb susceptibility to methimazole-induced insulin autoimmune syndrome [ ADR Type 5 ] Naturally processed peptides from two disease-resistance-associated HLA-DR13 alleles show related sequence motifs and the effects of the dimorphism at position 86 of the HLA
Methimazole Insulin Autoimmune Syndrome Allele specificity of structural requirement for peptides bound to HLA-DRB1 0405 and -DRB1 Allele specificity of structural requirement for peptides bound to HLA-DRB1 0405 and -DRB10406 complexes: implication for the HLA-associated susceptibility to methimazole-induced
Penicillamine D-Penicillamine Toxic Reactions The lowest frequency of side-effects was seen in patients with HLA-DR1 and DR2 of D-penicillamine toxic reactions [ ADR Type 5 ] HLA-A,-B, and -DR antigens in relation to GOld and D-penicillamine toxicity in Greek patients
Penicillamine Polymyositis The cumulative dose responsible for the DPA-induced polymyositis (PM) case amounted to 465 g. All the patients were HLA DR1. [ ADR Type 1 ] Neuromuscular disorders associated with D-penicillamine treatment for rheumatoid arthritis
Tiopronin Rheumatoid Arthritis A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis [ ADR Type 3 ] A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database