This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs |
Toxicity |
Mechanism |
Reference |
|---|
| Famotidine | Bone Marrow Failure | The interleukin 3-(IL-3) and granulocyte macrophage colony-stimulating factor-(GM-CSF) dependent growth was affected; a combination of growth factors (IL-3, GM-CSF, and G-CSF, the granulocyte colony-stimulating factor) resulted in a less reduced growth,which compatible with drug-induced bone marrow failure. [ ADR Type 5 ] | The growth capacity of hematopoietic progenitor cells in severe neutropenia induced by famotidine
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| Peplomycin (PLM) | Pulmonary Fibrosis | In vitro, peplomycin(PLM) up-regulated the release of interleukin-1 beta, interleukin-6, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor both from human cells and from RAM and pulmonary fibroblasts,which are the causative factors of PLM-induced pulmonary fibrosis [ ADR Type 2 ] | Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts
|
| Uracil Mustard | Delayed Inflammatory Skin Response | An increase in IL-1beta mRNA levels was first observed at 3 hours IL-1beta, GM-CSF, and IL-6 mRNA levels were dramatically increased at 6-24 hours postexposure,which is associated with HD-induced skin pathogenesis(delayed inflammatory skin response and severe tissue injury) [ ADR Type 5 ] | Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin
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| Uracil Mustard | Severe Tissue Injury | An increase in IL-1beta mRNA levels was first observed at 3 hours IL-1beta, GM-CSF, and IL-6 mRNA levels were dramatically increased at 6-24 hours postexposure,which is associated with HD-induced skin pathogenesis(delayed inflammatory skin response and severe tissue injury) [ ADR Type 5 ] | Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin
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This panel provides information on drug category