This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs |
Toxicity |
Mechanism |
Reference |
|---|
| Nicotine | Disintegration Of Cells | There was both a dose- and time-dependent response to nicotine, with constructs cultured in low-nicotine concentration media demonstrating an early increase in DNA, GAG, and collagen content,which included reduced cell proliferation, disrupted cell architecture, disintegration of cells, and extracellular matrix. [ ADR Type 1 ] | A Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration
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| Nicotine | Disrupted Cell Architecture | There was both a dose- and time-dependent response to nicotine, with constructs cultured in low-nicotine concentration media demonstrating an early increase in DNA, GAG, and collagen content,which included reduced cell proliferation, disrupted cell architecture, disintegration of cells, and extracellular matrix. [ ADR Type 1 ] | A Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration
|
| Nicotine | Extracellular Matrix | There was both a dose- and time-dependent response to nicotine, with constructs cultured in low-nicotine concentration media demonstrating an early increase in DNA, GAG, and collagen content,which included reduced cell proliferation, disrupted cell architecture, disintegration of cells, and extracellular matrix. [ ADR Type 1 ] | A Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration
|
| Nicotine | Reduced Cell Proliferation | There was both a dose- and time-dependent response to nicotine, with constructs cultured in low-nicotine concentration media demonstrating an early increase in DNA, GAG, and collagen content,which included reduced cell proliferation, disrupted cell architecture, disintegration of cells, and extracellular matrix. [ ADR Type 1 ] | A Effect of nicotine on spinal disc cells: a cellular mechanism for disc degeneration
|
| Penicillamine | Cutis Laxa | D-penicillamine (DPA) leads to side effects in different ways:collagen and elastin crosslinking are inhibited, which results in cutis laxa [ ADR Type 5 ] | D-penicillamine--side effects, pathogenesis and decreasing the risks
|
| Penicillamine | Elastosis Perforans Serpiginosa | D-penicillamine (DPA) leads to side effects in different ways:collagen and elastin crosslinking are inhibited, which results in elastosis perforans serpiginosa. [ ADR Type 5 ] | D-penicillamine--side effects, pathogenesis and decreasing the risks
|
| Penicillamine | Embryopathy | D-penicillamine (DPA) leads to side effects in different ways:collagen and elastin crosslinking are inhibited, which results in embryopathy. [ ADR Type 5 ] | D-penicillamine--side effects, pathogenesis and decreasing the risks
|
| Penicillamine | Thin And Vulnerable Skin | D-penicillamine (DPA) leads to side effects in different ways:collagen and elastin crosslinking are inhibited, which results in thin and vulnerable skin. [ ADR Type 5 ] | D-penicillamine--side effects, pathogenesis and decreasing the risks
|
| Penicillamine | Wound Healing Defects | D-penicillamine (DPA) leads to side effects in different ways:collagen and elastin crosslinking are inhibited, which results in wound healing defects [ ADR Type 5 ] | D-penicillamine--side effects, pathogenesis and decreasing the risks
|
| Peplomycin (PLM) | Pulmonary Fibrosis | Up-regulated RO and collagen generation are the causative factors of PLM-induced pulmonary fibrosis. [ ADR Type 2 ] | Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts
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