| Protein Name: | Insulin (P01308) |
|---|---|
| Gene Name: | INS |
| Description: | Insulin precursor [Contains: Insulin B chain; Insulin A chain] |
| PDB ID: | 1A7F |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Dehydrated Alcohol | Impairs Insulin | EtOH altered the distribution of eukaryotic initiation factor (eIF)4E, as evidenced by a decreased amount of active eIF4E eIF4G complex, an increased amount of inactive eIF4E-binding protein (BP)1 complex, and decreased 4E-BP1 phosphorylation,which impairs insulin and IGF-I stimulation of S6K1 [ ADR Type 2 ] | Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle |
| Triamcinolone | Stimulate Growth Of Nel-M1 Human Melanoma Cells | The 6- to 8-fold stimulation of cell growth by insulin and transferrin,SHOWING that triamcinolone acetonide stimulate growth of NEL-M1 human melanoma cells [ ADR Type 1 ] | Effect of triamcinolone acetonide on the growth of NEL-M1 human melanoma cells cultured in the presence and absence of growth stimulatory agents |
This panel provides information on drug category
| Toxicity | Source |
|---|