InAADR

Protein Information

Protein Name: Parathyroid hormone (P01270)
Gene Name: PTH
Description: Parathyroid hormone precursor (Parathyrin) (PTH) (Parathormone)
PDB ID: 1BWX
Protein Family:
Protein Category:

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Cimetidine Hyperparathyroidism the resting iPTH and CT levels were significantly higher in patients on RDT than in the healthy subjects,which led to symptoms of secondary hyperparathyroidism [ ADR Type 2 ] Acute effect of cimetidine and pirenzepine on plasma parathyroid hormone and calcitonin in haemodialyzed patients
Cisplatin Hypocalcemia High normal intact parathyroid hormone (PTH), elevated mid-region PTH and undetectable osteocalcin levels had already been found before the appearance of obvious symptoms concomitantly associated with moderate hypomagnesemia and hypocalcemia [ ADR Type 1 ] Tetany due to hypomagnesemia induced by cisplatin and doxorubicin treatment for synovial sarcoma Intern
Cisplatin Hypomagnesemia High normal intact parathyroid hormone (PTH), elevated mid-region PTH and undetectable osteocalcin levels had already been found before the appearance of obvious symptoms concomitantly associated with moderate hypomagnesemia and hypocalcemia [ ADR Type 1 ] Tetany due to hypomagnesemia induced by cisplatin and doxorubicin treatment for synovial sarcoma Intern
Cyclosporine Bone Loss Parathyroid hormone (PTH) and osteocalcin (BGP) increased by 90% and 800% respectively between pretransplantation values and 18 months after transplantation,which suggest Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation [ ADR Type 2 ] Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation
Doxorubicin Hypocalcemia High normal intact parathyroid hormone (PTH), elevated mid-region PTH and undetectable osteocalcin levels had already been found before the appearance of obvious symptoms concomitantly associated with moderate hypomagnesemia and hypocalcemia. [ ADR Type 1 ] Tetany due to hypomagnesemia induced by cisplatin and doxorubicin treatment for synovial sarcoma Intern
Doxorubicin Hypomagnesemia High normal intact parathyroid hormone (PTH), elevated mid-region PTH and undetectable osteocalcin levels had already been found before the appearance of obvious symptoms concomitantly associated with moderate hypomagnesemia and hypocalcemia. [ ADR Type 1 ] Tetany due to hypomagnesemia induced by cisplatin and doxorubicin treatment for synovial sarcoma Intern

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database