| Protein Name: | Transforming growth factor beta (P01137) |
|---|---|
| Gene Name: | TGFB1 |
| Description: | Transforming growth factor beta-1 precursor (TGF-beta-1) [Contains: Latency-associated peptide (LAP)] |
| PDB ID: | 1KLA |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cyclosporine | Csa-Induced Scarring In The Kidney | Transforming growth factor (TGF)-beta was shown to be upregulated along with matrix proteins in a model of CsA nephrotoxicity(CsA-induced scarring in the kidney) [ ADR Type 2 ] | Cyclosporine nephropathy: pathophysiology and clinical impact |
| Gabapentin | Diabetic Kidney Disease | Increased flux through the hexosamine biosynthetic pathway with glutamine:fructose-6-phosphate-amidotransferase (GFAT) as rate-limiting enzyme has been linked to the enhanced bioactivity of the prosclerotic cytokine transforming growth factor beta1 (TGF-beta1) in fibrotic complications, particularly in diabetic kidney disease. [ ADR Type 2 ] | Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-beta1 synthesis in NIH-3T3 fibroblasts |
This panel provides information on drug category
| Toxicity | Source |
|---|