This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs |
Toxicity |
Mechanism |
Reference |
|---|
| Apomorphine | Lesions | Repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions [ ADR Type 2 ] | Effects of repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions
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| Apomorphine | Rotational Behavior | Repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions [ ADR Type 2 ] | Effects of repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions
|
| Arsenic trioxide | Anemia | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Arsenic trioxide | Cardiovascular Disease | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Arsenic trioxide | Developmental Abnormalities | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Arsenic trioxide | Diabetes | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Arsenic trioxide | Eosinophilia | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Arsenic trioxide | Fibrosis Of Kidney | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Arsenic trioxide | Fibrosis Of Liver | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Arsenic trioxide | Hearing Loss | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Arsenic trioxide | Leukopenia | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Arsenic trioxide | Neurologic And Neurobehavioral Disorder | The CAT-Tox (L) assay showed statistically significant inductions(p [ ADR Type 2 ] | Arsenic trioxide-induced transcriptional activation of stress genes and expression of related proteins in human liver carcinoma cells (HepG2)
|
| Carbachol | Caudal-Rostral Seizure Generalization | Rats with seizures induced by PAG carbachol microinjections exhibited dense c-fos-like immunoreactivity in the dentate gyrus,which is proposed that the PAG serves as a pathway for caudal-rostral seizure generalization [ ADR Type 1 ] | Focal microinjection of carbachol into the periaqueductal gray induces seizures in the forebrain of the rat
|
| Chloroxine | Apoptosis | Expression of immediate early genes, including c-jun, c-fos and egr-1, was also induced by copper treatment in these cells,which suggests copper,in the presence of 8-hydroxyquinoline, was able to induce apoptosis of murine J774 A1 cells in culture [ ADR Type 2 ] | Copper-induced apoptosis and immediate early gene expression in macrophages
|
| Dehydrated Alcohol | Alcohol Intoxication | Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus through activation of the MEK1/2-ERK1/2-Stat3 pathway,showing that the Edinger-Westphal nucleus is preferentially sensitive to alcohol intoxication [ ADR Type 2 ] | Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms
|
| Levodopa | Lesions | Repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions [ ADR Type 2 ] | Effects of repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions
|
| Levodopa | Rotational Behavior | Repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions [ ADR Type 2 ] | Effects of repeated methyl levodopa administration on apomorphine sensitivity of rotational behavior and striatal Fos expression of rats with unilateral 6-OHDA lesions
|
| MK-801 | Depression | Effects of the NMDA antaGOnist MK-801 on the expression of mRNA for GFAP and c-fos and demonstrated a marked reduction in the upregulation of these genes,application of high K+ concentrations to a limited area of the brain surface is known to trigger spreading depression [ ADR Type 2 ] | Analysis of c-Fos and glial fibrillary acidic protein (GFAP) expression following topical application of potassium chloride (KCl) to the brain surface
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| Penicillin v | Depression | c-Fos protein(s) expression was high at 1 5 h and decreased at 24 h after K+ exposure and c-fos mRNA expression correlated with the immunohistochemical results, application of high K+ concentrations to a limited area of the brain surface is known to trigger spreading depression [ ADR Type 5 ] | Analysis of c-Fos and glial fibrillary acidic protein (GFAP) expression following topical application of potassium chloride (KCl) to the brain surface
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