| Protein Name: | Metalloproteinase inhibitor 1 (P01033) |
|---|---|
| Gene Name: | TIMP1 |
| Description: | Metalloproteinase inhibitor 1 precursor (TIMP-1) (Erythroid potentiating activity) (EPA) (Tissue inhibitor of metalloproteinases) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) |
| PDB ID: | 1D2B |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Pentoxifylline | Antifibrogenic Action | PTF markedly reduced the expression of tissue inhibitor of metalloproteinase 1 (TIMP-1) mRNA,suggest that the antifibrogenic action of PTF on human HSCs is mainly mediated by extracellular collagen degradation. [ ADR Type 1 ] | Effect of pentoxifylline on the degradation of procollagen type I produced by human hepatic stellate cells in response to transforming growth factor-beta |
This panel provides information on drug category
| Toxicity | Source |
|---|