| Protein Name: | Adenosine deaminase (P00813) |
|---|---|
| Gene Name: | ADA |
| Description: | Adenosine deaminase (EC 3 5 4 4) (Adenosine aminohydrolase) |
| PDB ID: | 1M7M |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Adenosine | Ada Immunodeficiency (Scid) | Both intracellular toxicity and signaling by extracellular adenosine may contribute to pathogenesis of ADA immunodeficiency (SCID) [ ADR Type 5 ] | The extracellular versus intracellular mechanisms of inhibition of TCR-triggered activation in thymocytes by adenosine under conditions of inhibited adenosine deaminase |
| Adenosine, deoxyadenosine and deoxyguanosine | Cell Lysis | The DNA cleavage and subsequent cell lysis might be related to the selective thymocyte deletion observed in patients with adenosine deaminase deficiency [ ADR Type 2 3 ] | Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes |
This panel provides information on drug category
| Toxicity | Source |
|---|