This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs |
Toxicity |
Mechanism |
Reference |
|---|
| Adenosine, deoxyadenosine and deoxyguanosine | Cell Lysis | The inhibition of DNA cleavage was accompanied by a reduction in lactate dehydrogenase release, suggesting a causal relationship between DNA cleavage and cell death [ ADR Type 2 3 ] | Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes
|
| Adenosine, deoxyadenosine and deoxyguanosine | Thymocyte Deletion | The inhibition of DNA cleavage was accompanied by a reduction in lactate dehydrogenase release, suggesting a causal relationship between DNA cleavage and cell death [ ADR Type 2 3 ] | Adenosine, deoxyadenosine, and deoxyguanosine induce DNA cleavage in mouse thymocytes
|
| Chlorpromazine | Hepatotoxicity | A toxic dose of the drug (LD20)produced elevated serum glutamate-pyruvate transaminase and lactate dehydrogenase activities 20-24 hr after drug administration,which leads to hepatotoxicity of acetaminophen in neonatal and young rats. [ ADR Type 1 ] | Hepatotoxicity of acetaminophen in neonatal and young rats I Age-related changes in susceptibility
|
| Cisplatin | Nephrotoxicity | Cisplatin increased urinary excretion of LDH (six-fold), GGT (twofold), and NAG (twofold); CI-973 and carboplatin increased GGT excretion (approximately twofold),which produced marked nephrotoxicity as determined by biochemical, functional, and histopathologic endpoints [ ADR Type 2 ] | Comparative nephrotoxicity of a novel platinum compound, cisplatin, and carboplatin in male
|
| Tobramycin | Nephrotoxicity | Treatment with TOB alone resulted in marked increases in the activities of lactate dehydrogenase,which leads to Effect of latamoxef (LMOX) against tobramycin (TOB)-induced nephrotoxicity. [ ADR Type 2 ] | Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (3) Protective effect of latamoxef against tobramycin nephrotoxicity and its protective mechanism
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This panel provides information on drug category