| Protein Name: | protein kinase-C (P00047) |
|---|---|
| Gene Name: | Not Available |
| Description: | |
| PDB ID: | |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cisplatin | Cytotoxicity | Protein kinase C (PKC)-related signal transduction pathways may modulate cisplatin-induced cytotoxicity. [ ADR Type 2 ] | Role of protein kinase C in cisplatin nephrotoxicity |
| Troglitazone | Beneficial For The Diabetic Heart | Troglitazone induced a dose-dependent increase in 2-deoxyglucose uptake reaching a 40-fold stimulation at 5 mumol/l,This was paralleled by a dose-dependent increase of Glucose transporter-1 (GLUT1) and GLUT4 protein expression;troglitazone exerts multiple effects on cardiomyocytes involving inhibition of PKC and regulation of Glucose transporter expression and distribution which may be beneficial for the diabetic heart and that modulation of PKC-activity could be relevant for improving insulin action in muscle tissue [ ADR Type 1 ] | Acute and chronic effects of troglitazone (CS-045) on isolated rat ventricular cardiomyocytes |
This panel provides information on drug category
| Toxicity | Source |
|---|---|
| Apoptosis | Rapid induction of apoptosis in human gastric cancer cell lines by sorbitol |