| Protein Name: | BCR-ABL (b3a2) (P00004) |
|---|---|
| Gene Name: | Not Available |
| Description: | |
| PDB ID: | |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Hydroxyurea | Abnormality Of Hepatomegaly | The administration of hydroxyurea was associated with characteristic t(9;22)(q34;q11) chromosomal translocation and the bcr-abl (b3a2) DNA fusion,which lead to thalassaemia major. [ ADR Type 3 ] | Chronic myeloid leukaemia with marked thrombocytosis in a patient with thalassaemia major: complete haematological remission under the combination of hydroxyurea and anagrelid |
| Hydroxyurea | Myeloid Leukaemia | The administration of hydroxyurea was associated with characteristic t(9;22)(q34;q11) chromosomal translocation and the bcr-abl (b3a2) DNA fusion,which leads to chronic myeloid leukaemia (CML) [ ADR Type 3 ] | Chronic myeloid leukaemia with marked thrombocytosis in a patient with thalassaemia major: complete haematological remission under the combination of hydroxyurea and anagrelid |
This panel provides information on drug category