| Protein Name: | Heat shock 70 kDa protein (O43301) |
|---|---|
| Gene Name: | HSPA12A |
| Description: | Heat shock 70 kDa protein 12A |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Indomethacin | Denatured Proteins | In these cells,the 70-kDa constitutive heat shock protein exhibited an enhanced aggregation in the presence of indomethacin,suggestting that indomethacin at moderate temperatures accelerates the presence of denatured proteins in the cell, thus lowering the temperature threshold for a heat shock response [ ADR Type 1 ] | Enhanced protein denaturation in indomethacin-treated cells Cell Stress |
| Zalcitabine | Cardiotoxicity | A decrease in the quantity of heat shock protein (HSP)70s was also detected,which suggests that the short term cardiotoxicity of ddC is partially based on ROS-mediated signalling. [ ADR Type 2 ] | Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions |
This panel provides information on drug category
| Toxicity | Source |
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