| Protein Name: | Canalicular multispecific organic anion transporter (O15438) |
|---|---|
| Gene Name: | ABCC3 |
| Description: | Canalicular multispecific organic anion transporter 2 (Multidrug resistance-associated protein 3) (Multi-specific organic anion transporter-D) (MOAT-D) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Transporters |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Ivermectin | Cytotoxicity | Ivermectin efficiently inhibites the fully activated ATPase of MRP3 with respective IC50 values of 40 ? 20 ?M, thus increases the Cytotoxicity of verapamil [ ADR Type 4 ] | P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells |
This panel provides information on drug category
| Toxicity | Source |
|---|