| Protein Name: | Carboxylesterase 2 (O00748) |
|---|---|
| Gene Name: | CES2 |
| Description: | Carboxylesterase 2 precursor (EC 3 1 1 1) (CE-2) (hCE-2) |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Esmolol | Selective Prodrug Activation | hCE-2 was 26-fold more active than human carboxylesterase 1 and was 65% as active as rabbit liver carboxylesterase, the most active CPT-11 hydrolyzing enzyme known These results confirm the importance of hCE-2 for CPT-11 activation and underscore the importance of enzyme kinetics for selective prodrug activation [ ADR Type 1 ] | Identification and activities of human carboxylesterases for the activation of CPT-11, a clinically approved anticancer drug |
This panel provides information on drug category
| Toxicity | Source |
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