| Protein Name: | DNA-directed RNA polymerase mitochondrial (O00411) |
|---|---|
| Gene Name: | POLRMT |
| Description: | DNA-directed RNA polymerase, mitochondrial precursor (EC 2 7 7 6) (MtRPOL) |
| PDB ID: | 3SPA |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Didanosine | Mtdna Depletion | Didanosine can inhibit mitochondrial (mt)DNA polymerase and cause termination of synthesis of growing mtDNA strands and mtDNA depletion [ ADR Type 1 ] | Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells |
| Zalcitabine | Mtdna Depletion | Zalcitabine can inhibit mitochondrial (mt)DNA polymerase and cause termination of synthesis of growing mtDNA strands and mtDNA depletion [ ADR Type 1 ] | Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells |
| Zidovudine | Mtdna Depletion | Zidovudine can inhibit mitochondrial (mt)DNA polymerase and cause termination of synthesis of growing mtDNA strands and mtDNA depletion [ ADR Type 1 ] | Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells |
| Zidovudine | Termination Of Synthesis Of Mtdna Strands | Zidovudine can inhibit mitochondrial (mt)DNA polymerase and cause termination of synthesis of growing mtDNA strands and mtDNA depletion [ ADR Type 1 ] | Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells |
This panel provides information on drug category
| Toxicity | Source |
|---|