| Protein Name: | Nitric-oxide synthase endothelial (P29474) |
|---|---|
| Gene Name: | NOS3 |
| Description: | Nitric-oxide synthase, endothelial (EC 1141339) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS) |
| PDB ID: | 1M9J |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Bosentan | Hepatopulmonary Syndrome | Biliary cirrhosis in the rat triggers intrapulmonary vasodilatation and gas exchange abnormalities that characterize the hepatopulmonary syndrome. This vasodilatation correlates with increased levels of pulmonary microcirculatory endothelial nitric oxide synthase (eNOS) and hepatic and plasma endothelin-1 (ET-1). [ ADR Type 2 ] | Endothelin-1 stimulation of endothelial nitric oxide synthase in the pathogenesis of hepatopulmonary syndrome |
This panel provides information on drug category
| Toxicity | Source |
|---|---|
| Hypertension | Effects of chronic neutral endopeptidase inhibition in rats with cyclosporine-induced hypertension |