| Protein Name: | Myeloperoxidase precursor (P05164) |
|---|---|
| Gene Name: | MPO |
| Description: | |
| PDB ID: | 1CXP |
| Protein Family: | PF03098, PS00435 |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Respiratory Burst | Myeloperoxidase appears to be much more important in the binding of acetaminophen to DNA than it is in the DNA binding of arylamines in general@causing the respiratory burst the bioactivation of certain arylamines [ ADR Type 2 3 ] | Metabolic activation and nucleic acid binding of acetaminophen and related arylamine substrates by the respiratory burst of human granulocytes |
| Acetylsalicylic acid | Haemorrhagic Erosions | Aspirin caused more extensive haemorrhagic erosions (33 1 (12 3) mm2) associated with greater Myeloperoxidase (MPO)activity (1887 7 (598 5) microU/mg protein) and TBARS (0 33 (0 14) nmol/mg protein) and KC/GRO concentrations (28 3 (9 5) pg/mg protein) in infected than in uninfected gerbils (13 7 (2 3); 204 0 (68 9); 0 12 (0 06); 3 1 (0 8)@ respectively) [ ADR Type 2 ] | Aspirin injury and H pylori |
| Allopurinol | Ischemia | The MPO activity was the lowest in ICAMG@ and uric acid level was significantly decreased in ALLOG compared with the other groups Methylene blue decreased TNF-alpha response to reperfusion injury but significantly increased the grade of the mucosal damage and the MPO activity [ ADR Type 5 ] | Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury |
| Allopurinol | Reperfusion Injury | The MPO activity was the lowest in ICAMG@ and uric acid level was significantly decreased in ALLOG compared with the other groups Methylene blue decreased TNF-alpha response to reperfusion injury but significantly increased the grade of the mucosal damage and the MPO activity [ ADR Type 5 ] | Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury |
| Amodiaquine | Hepatotoxicity | Associated with idiosyncratic hepatotoxicity [ ADR Type 2 ] | Myeloperoxidase as a generator of drug free radicals |
| Clonidine | Agranulocytosis | The oxidation of clozapine by the combination of myeloperoxidase to a reactive nitrenium ion that irreversibly binds to the cells@which could be responsible for clozapine-induced agranulocytosis. [ ADR Type 3 ] | Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells |
| Dapsone | Agranulocytosis | N-chlorosulfamethoxazole product was formed when dapsone was N-chlorinated by the MPO system@which is responsible for agranulocytosis. [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
| Dapsone | Lupus | N-chlorosulfamethoxazole product was formed when dapsone was N-chlorinated by the MPO system@which is responsible for drug-induced lupus [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
| Dehydrated Alcohol | Pancreatitis | Pancreatic tissue and blood samples were assessed for reduced (GSH) and ixidized (GSSG) glutathione@ malondialdehyde@ conjugated dienes (CD)@ and myeloperoxidase@suggesting the influence of ethanol on the pancreatic generation of oxygen-free radicals (OFR) in alcohol-induced acute pancreatitis as one possible pathway of proenzyme activation in this disease [ ADR Type 1 ] | Oxygen radical production precedes alcohol-induced acute pancreatitis in rats |
| Ibuprofen | Haemorrhagic Infarction | MPO can be used as a sensitive and quantitative marker of polymorphonuclear leukocytes (PMN) accumulation into an evolving myocardial infarction (MI)@and pretreatment with ibuprofen increased the incidence of haemorrhagic infarction. [ ADR Type 3 ] | Myeloperoxidase activity as a quantitative marker of polymorphonuclear leukocyte accumulation into an experimental myocardial infarct--the effect of ibuprofen on infarct size and polymorphonuclear |
| Ibuprofen | Ventricular Fibrillation | MPO can be used as a sensitive and quantitative marker of polymorphonuclear leukocytes (PMN) accumulation into an evolving myocardial infarction (MI)@and pretreatment with ibuprofen increased the incidence of ventricular fibrillation [ ADR Type 3 ] | Myeloperoxidase activity as a quantitative marker of polymorphonuclear leukocyte accumulation into an experimental myocardial infarct--the effect of ibuprofen on infarct size and polymorphonuclear |
| Indomethacin | Gastric Damage | Treatment with thalidomide@ dexamethasone@ or fucoidin reduced gastric damage and MPO activity induced by indomethacin. After indomethacin administration@ TNF-R1-/- had less gastric damage and MPO activity than controls. [ ADR Type 1 ] | Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice |
| Indomethacin | Granulocyte Infiltration | Treatment with thalidomide@ dexamethasone@ or fucoidin reduced gastric damage and MPO activity induced by indomethacin. After indomethacin administration@ TNF-R1-/- had less gastric damage and MPO activity than controls. [ ADR Type 1 ] | Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice |
| Mercuric Chloride | Autoimmune Syndrome | Mercuric chloride (HgCl2) treatment induces an autoimmune syndrome in the Brown Norway (BN) rat when anti-myeloperoxidase (MPO) and anti-glomerular basement (GBM) antibodies are present. [ ADR Type 3 ] | Use of methyl prednisolone and antioxidants in mercuric chloride-induced experimental vasculitis |
| Mercuric Chloride | Leucocytoclastic Vasculitis | Mercuric chloride (HgCl2) treatment induces an necrotizing leucocytoclastic vasculitis in the Brown Norway (BN) rat when anti-myeloperoxidase (MPO) and anti-glomerular basement (GBM) antibodies are present. [ ADR Type 3 ] | Use of methyl prednisolone and antioxidants in mercuric chloride-induced experimental vasculitis |
| P-chloroaniline | Respiratory Burst | Myeloperoxidase appears to be much more important in the binding of p-chloroaniline to DNA than it is in the DNA binding of arylamines in general@causing the respiratory burst the bioactivation of certain arylamines. [ ADR Type 2 3 ] | Metabolic activation and nucleic acid binding of acetaminophen and related arylamine substrates by the respiratory burst of human granulocytes |
| Phenetidine | Respiratory Burst | Myeloperoxidase appears to be much more important in the binding of p-phenetidine to DNA than it is in the DNA binding of arylamines in general@causing the respiratory burst the bioactivation of certain arylamines [ ADR Type 2 3 ] | Metabolic activation and nucleic acid binding of acetaminophen and related arylamine substrates by the respiratory burst of human granulocytes |
| sulfamethoxazole | Agranulocytosis | Activation of neutrophils or monocytes leads to the formation of hydrogen peroxide and the release of myeloperoxidase (MPO)@which is responsible for agranulocytosis. [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
| sulfamethoxazole | Lupus | Activation of neutrophils or monocytes leads to the formation of hydrogen peroxide and the release of myeloperoxidase (MPO)@which is responsible for drug-induced lupus. [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
| Sulfasalazine | Vasculitis | Perinuclear antineutrophil cytoplasmic antibodies with specificity for myeloperoxidase were found critically increased just before the occurrence of vasculitis. [ ADR Type 3 ] | Sulfasalazine induced lupus in rheumatoid arthritis |
This panel provides information on drug category
| Toxicity | Source |
|---|---|
| Vasculitis | Anti-oxidized low-density lipoprotein antibodies in myeloperoxidase-positive vasculitis patients preferentially recognize hypochlorite-modified low density lipoproteins |