| Protein Name: | Mitogen-activated protein kinase 14 (Q16539) |
|---|---|
| Gene Name: | MAPK14 |
| Description: | |
| PDB ID: | 1A9U |
| Protein Family: | PF00069, PS01351 |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cisplatin | Apoptosis | p38 was also activated by cisplatin with similar kinetics as JNK [ ADR Type 2 ] | Lack of c-Jun activity increases survival to cisplatin |
| Haloperidol | Neuronal Apoptosis | The c-Jun-NH(2)-terminal protein kinase and p38 mitogen-activated protein kinase were activated within 1 h and were sustained over the next 3 h following exposure of cortical neurons to haloperidol@which leads to Haloperidol-induced neuronal apoptosis [ ADR Type 2 ] | Haloperidol-induced neuronal apoptosis: role of p38 and c-Jun-NH(2)-terminal protein kinase |
This panel provides information on drug category