| Protein Name: | Mitogen-activated protein kinase 11 (Q15759) |
|---|---|
| Gene Name: | MAPK11 |
| Description: | Mitogen-activated protein kinase 11 (EC 271124) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (p38-2) (Stress- activated protein kinase 2) |
| PDB ID: | 3GC8 |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Adenosine | Tactile Allodynia | Tactile allodynia under the chronic pain state requires an activation of the P2X(4) ionotropic ATP receptor and p38 mitogen-activated protein kinase (MAPK) in spinal cord microglia. [ ADR Type 1 2 ] | ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4 |
| Dexamethasone | Apoptosis | Dex-induced apoptosis is associated with a significant decrease in the activities of mitogen activated protein kinase (MAPK) and p70S6K. [ ADR Type 2 ] | Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism |
This panel provides information on drug category
| Toxicity | Source |
|---|