InAADR

Protein Information

Protein Name: Kappa-Type opioid receptor (P41145)
Gene Name: OPRK1
Description:
PDB ID: 2A0D
Protein Family: PF00001, PS00237
Protein Category: Membrane Receptors

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Clemastine Constipation Not Available Large-scale prediction and testing of drug activity on side-effect targets
Clemastine Dry Mouth Not Available Large-scale prediction and testing of drug activity on side-effect targets
Clemastine Tachycardia Not Available Large-scale prediction and testing of drug activity on side-effect targets
Clobutinol Dry Mouth Not Available Large-scale prediction and testing of drug activity on side-effect targets
Clobutinol Insomnia Not Available Large-scale prediction and testing of drug activity on side-effect targets
Clonidine Side Effects Of Clozapine Effects of clozapine on the delta- and kappa-opioid receptors and the G-protein-activated K+ (GIRK) channel expressed in Xenopus oocytes@which suggests efficacy and side effects of clozapine under clinical conditions may be partly due to activation of the delta-opioid receptor and blockade of the GIRK channel. [ ADR Type 1 ] Effects of clozapine on the delta- and kappa-opioid receptors and the G-protein-activated K+ (GIRK) channel expressed in Xenopus oocytes
Cyclobenzaprine Nervousness Not Available Large-scale prediction and testing of drug activity on side-effect targets
Cyclobenzaprine Somnolence Not Available Large-scale prediction and testing of drug activity on side-effect targets
Cyclobenzaprine Tachycardia Not Available Large-scale prediction and testing of drug activity on side-effect targets
Cyclobenzaprine Tinnitus Not Available Large-scale prediction and testing of drug activity on side-effect targets
Cyclobenzaprine Tremor Not Available Large-scale prediction and testing of drug activity on side-effect targets
Encainide Constipation Not Available Large-scale prediction and testing of drug activity on side-effect targets
Encainide Death Not Available Large-scale prediction and testing of drug activity on side-effect targets
Encainide Mental Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets
Encainide Respiratory Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets
Encainide Somnolence Not Available Large-scale prediction and testing of drug activity on side-effect targets
Ranitidine Constipation Not Available Large-scale prediction and testing of drug activity on side-effect targets
Reserpine Ejaculation Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets
Reserpine Nasal Congestion Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides information on drug category

Toxicity Source
Biliary Colic Large-scale prediction and testing of drug activity on side-effect targets
Bladder Disorder Large-scale prediction and testing of drug activity on side-effect targets
Bradycardia Large-scale prediction and testing of drug activity on side-effect targets
Cerebrovascular Disorder Large-scale prediction and testing of drug activity on side-effect targets
Coma Large-scale prediction and testing of drug activity on side-effect targets
Constipation Large-scale prediction and testing of drug activity on side-effect targets
Death Large-scale prediction and testing of drug activity on side-effect targets
Dependence Large-scale prediction and testing of drug activity on side-effect targets
Dermatitis Contact Large-scale prediction and testing of drug activity on side-effect targets
Drug Tolerance Large-scale prediction and testing of drug activity on side-effect targets
Dysphoria Large-scale prediction and testing of drug activity on side-effect targets
Dysuria Large-scale prediction and testing of drug activity on side-effect targets
Euphoric Mood Large-scale prediction and testing of drug activity on side-effect targets
Hyperhidrosis Large-scale prediction and testing of drug activity on side-effect targets
Hypothermia Large-scale prediction and testing of drug activity on side-effect targets
Injection Site Irritation Large-scale prediction and testing of drug activity on side-effect targets
Injection Site Pain Large-scale prediction and testing of drug activity on side-effect targets
Intracranial Pressure Increased Large-scale prediction and testing of drug activity on side-effect targets
Mental Disorder Large-scale prediction and testing of drug activity on side-effect targets
Miosis Large-scale prediction and testing of drug activity on side-effect targets
Mood Altered Large-scale prediction and testing of drug activity on side-effect targets
Muscle Spasms Large-scale prediction and testing of drug activity on side-effect targets
Oliguria Large-scale prediction and testing of drug activity on side-effect targets
Orthostatic Hypotension Large-scale prediction and testing of drug activity on side-effect targets
Pruritus Large-scale prediction and testing of drug activity on side-effect targets
Respiratory Depression Large-scale prediction and testing of drug activity on side-effect targets
Respiratory Disorder Large-scale prediction and testing of drug activity on side-effect targets
Restlessness Large-scale prediction and testing of drug activity on side-effect targets
Shock Large-scale prediction and testing of drug activity on side-effect targets
Somnolence Large-scale prediction and testing of drug activity on side-effect targets
Ureteral Spasm Large-scale prediction and testing of drug activity on side-effect targets
Withdrawal Syndrome Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database