This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs |
Toxicity |
Mechanism |
Reference |
|---|
| Dexamethasone | Apoptosis | Removal of IL-6 in four IL-6-dependent myeloma cell lines induce apoptosis when treating with dexamethasone [ ADR Type 5 ] | IFN-alpha is a survival factor for human myeloma cells and reduces dexamethasone-induced apoptosis
|
| Ibritumomab | Pathogenesis Of Side-Effects | Infusion of rituximab induced rapid complement activation@ preceding the release of TNF-alpha@ IL-6 and IL-8@which is correlated with pathogenesis of side-effects. [ ADR Type 5 ] | Complement activation plays a key role in the side-effects of rituximab treatment
|
| Methylprednisolone | Thrombocytopenic Purpura (Itp) | The posttreatment of methylprednisolone IL-6 and TPO declined (P [ ADR Type 5 ] | Soluble P-selectin, interleukin 6, and thrombopoietin levels in children with acute and chronic idiopathic thrombocytopenic purpura and their relationship with mega-dose methylprednisolone therapy: a pilot study
|
| Pentoxifylline | Inflammation | PTX induced an up- or a down-regulation (in PMA + PHA or LPS stimulated cells, respectively) for IL-1 and IL-6 release,which plays a key role in inflammation [ ADR Type 5 ] | Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline
|
| Peplomycin (PLM) | Pulmonary Fibrosis | In vitro@ peplomycin(PLM) up-regulated the release of interleukin-1 beta@ interleukin-6@ tumor necrosis factor alpha@ and granulocyte-macrophage colony-stimulating factor both from human cells and from RAM and pulmonary fibroblasts@which are the causative factors of PLM-induced pulmonary fibrosis [ ADR Type 2 ] | Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts
|
| Uracil Mustard | Delayed Inflammatory Skin Response | An increase in IL-1beta mRNA levels was first observed at 3 hours IL-1beta@ GM-CSF@ and IL-6 mRNA levels were dramatically increased at 6-24 hours postexposure@which is associated with HD-induced skin pathogenesis(delayed inflammatory skin response and severe tissue injury) [ ADR Type 5 ] | Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin
|
| Uracil Mustard | Tissue Injury | An increase in IL-1beta mRNA levels was first observed at 3 hours IL-1beta@ GM-CSF@ and IL-6 mRNA levels were dramatically increased at 6-24 hours postexposure@which is associated with HD-induced skin pathogenesis(delayed inflammatory skin response and severe tissue injury) [ ADR Type 5 ] | Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin
|