| Protein Name: | Interleukin-1 (P01583) |
|---|---|
| Gene Name: | IL1A |
| Description: | Interleukin-1 alpha precursor (IL-1 alpha) (Hematopoietin-1) |
| PDB ID: | 1ITA |
| Protein Family: | |
| Protein Category: | Secreted Protein |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| 12-O-tetradecanoylphorbol-13-acetate (TPA) | Carcinogenesis | Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor-alpha (TNF-alpha),which leads to murine multistage carcinogenesis. [ ADR Type 5 ] | Inhibition of pro-inflammatory cytokine gene expression and papilloma growth during murine multistage carcinogenesis by pentoxifylline |
| Amphotericin B | Neurotoxicity | AMB-mediated enhancement of astrocyte NO production was partly dependent on endogenous IL-1, as shown by partial inhibition of AMB effect with IL-1 receptor antaGOnist,which might be at least partly responsible for AMB neurotoxicity [ ADR Type 5 ] | Amphotericin B potentiates the activation of inducible nitric oxide synthase and causes nitric oxide-dependent mitochondrial dysfunction in cytokine-treated rodent |
This panel provides information on drug category
| Toxicity | Source |
|---|