| Protein Name: | Intercellular adhesion molecule 1 precursor (P05362) |
|---|---|
| Gene Name: | ICAM1 |
| Description: | Intercellular adhesion molecule 1 precursor (ICAM-1) (Major group rhinovirus receptor) (CD54 antigen) |
| PDB ID: | 1D3E |
| Protein Family: | |
| Protein Category: | Adhesion |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Allopurinol | Intestinal Ischemia | Prereperfusion application of allopurinol and monoclonal antibody to the adhesion molecule ICAM-1 may attenuate the damage caused by intestinal ischemia and reperfusion [ ADR Type 5 ] | Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury |
| Dicloxacillin | Infusion Phlebitis | Despite constitutive expression of ICAM-1 (34%) in HUVEC@ dicloxacillin or erythromycin significantly increased the number of cells with ICAM-1 expression by 37% and 30%@ respectively@which leads to pathogenesis of infusion phlebitis [ ADR Type 1 ] | Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis |
| Erythromycin | Pathogenesis Of Infusion Phlebitis | Despite constitutive expression of ICAM-1 (34%) in HUVEC@ dicloxacillin or erythromycin significantly increased the number of cells with ICAM-1 expression by 37% and 30%@ respectively@which leads to pathogenesis of infusion phlebitis. [ ADR Type 1 ] | Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells: a possible factor in the pathogenesis of infusion phlebitis |
| Indomethacin | Gastropathy | Indomethacin induced gastropathy in CD18@ intercellular adhesion molecule 1@ or P-selectin deficient mice. [ ADR Type 3 ] | Indomethacin induced gastropathy in CD18, intercellular adhesion molecule 1, or P-selectin deficient mice Gut |
| maleate | Hepatic Injury | Endotoxin in plasma@ intercellular adhesion molecule 1 expression in hepatic sinusoidal-lining cells@ and the number of infiltrating inflammatory cells in the liver were 2-2.5-fold greater in females than males@which possibly account for increased hepatic injury due to ethanol in the female. [ ADR Type 2 ] | Female rats exhibit greater susceptibility to early alcohol-induced liver injury than males |
This panel provides information on drug category
| Toxicity | Source |
|---|