| Protein Name: | Integrin alpha-V (P06756) |
|---|---|
| Gene Name: | ITGAV |
| Description: | Integrin alpha-V precursor (Vitronectin receptor alpha subunit) (CD51 antigen) [Contains: Integrin alpha-V heavy chain; Integrin alpha-V light chain] |
| PDB ID: | |
| Protein Family: | |
| Protein Category: | Membrane Receptors |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| urokinase-type Plasminogen activator (pro-u-PA) | Cell Cytoskeleton Reorganization | Induced a chemotactic response in rat smooth muscle cells (RSMC) through binding to the membrane receptor of urokinase (u-PA receptor [u-PAR]);Pro-u-PA induced a decrease in stress fiber content@ membrane ruffling@ actin ring formation@ and disruption leading to the characteristic elongated cell shape of motile cells with an actin semi-ring located close to the leading edge of cells@ leading to cell cytoskeleton reorganization and cell migration [ ADR Type 1 ] | Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells |
| urokinase-type Plasminogen activator (pro-u-PA) | Cell Migration | Induced a chemotactic response in rat smooth muscle cells (RSMC) through binding to the membrane receptor of urokinase (u-PA receptor [u-PAR]);Pro-u-PA induced a decrease in stress fiber content@ membrane ruffling@ actin ring formation@ and disruption leading to the characteristic elongated cell shape of motile cells with an actin semi-ring located close to the leading edge of cells@ leading to cell cytoskeleton reorganization and cell migration [ ADR Type 1 ] | Src-dependence and pertussis-toxin sensitivity of urokinase receptor-dependent chemotaxis and cytoskeleton reorganization in rat smooth muscle cells |
This panel provides information on drug category
| Toxicity | Source |
|---|