| Protein Name: | Hypoxanthine-guanine phosphoribosyltransferase (P00492) |
|---|---|
| Gene Name: | HPRT1 |
| Description: | |
| PDB ID: | 1BZY |
| Protein Family: | PF00156, PS00103 |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Etoposide | Induced Dna Recombination | Hypoxanthine phosphoribosyl transferase (hprt) gene mutations and VP-16-induced mutant frequencies at the hprt locus were 5-10 times less in BCL-2/2 and BCL-2/4 cells than those observed in the V79 or NeoR control cells,which may lead to etoposide (VP-16)-induced DNA recombination [ ADR Type 3 ] | Inhibition of etoposide (VP-16)-induced DNA recombination and mutant frequency by Bcl-2 protein overexpression |
This panel provides information on drug category
| Toxicity | Source |
|---|---|
| Hyperuricemia | Identification of 17 independent mutations responsible for human hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency |