| Protein Name: | Hyaluronidase (Q12794) |
|---|---|
| Gene Name: | HYAL1 |
| Description: | Hyaluronidase-1 precursor (EC 3 2 1 35) (Hyal-1) (Hyaluronoglucosaminidase-1) (LUCA-1) |
| PDB ID: | 2PE4 |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Dactinomycin | Cytotoxicity | Binding and Western-blotting analyses revealed that hyaluronidase downregulated the intra-TBP@suggestting that serum fetuin and intraTBP are involved in the hyaluronidase induction of TNF/ ActD resistance@which makes fibrosarcoma cells resistant to tumor necrosis factor and Fas cytotoxicity [ ADR Type 2 ] | Hyaluronidase induces murine L929 fibrosarcoma cells resistant to tumor necrosis factor and Fas cytotoxicity in the presence of actinomycin D |
This panel provides information on drug category
| Toxicity | Source |
|---|