| Protein Name: | Glutathione peroxidase 1 (P07203) |
|---|---|
| Gene Name: | GPX1 |
| Description: | Glutathione peroxidase 1 (EC 1 11 1 9) (GSHPx-1) (GPx-1) (Cellular glutathione peroxidase) |
| PDB ID: | 2F8A |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cephaloridine | Impair Antioxidant Status | Selenium deficiency impaired antioxidant status and enhanced cephaloridine-induced injury [ ADR Type 3 ] | Cephaloridine nephrotoxicity is potentiated by selenium deficiency but not copper deficiency in rats |
| Cephaloridine | Nephrotoxicity | Selenium deficiency potentiated cephaloridine nephrotoxicity [ ADR Type 3 ] | Cephaloridine nephrotoxicity is potentiated by selenium deficiency but not copper deficiency in rats |
| Cisplatin | Nephrotoxicity | Treatment of rats with cisplatin or with cisplatin after chronic pre-exposure to cadmium induced a decrease in kidney cytochrome P-450 and glutathione levels@ and in glutathione peroxidase and reductase activities. And cadmium nephrotoxicity was characterized by tubular proximal damage with mitochondrial and lysosomal changes and a widespread vesiculation of tubular cells. [ ADR Type 1 ] | Cisplatin nephrotoxicity in cadmium-pretreated rats Enzymatic, functional and morphological studies |
| Cisplatin | Ototoxicity | Cisplatin ototoxicity is related to depletion of glutathione and glutathione peroxidase in the cochlea. [ ADR Type 2 ] | Application of antioxidants and other agents to prevent cisplatin ototoxicity |
| Cyclophosphamide | Lung Toxicity | Significant reductions (P less than 0 005) in G6PD@ GSH-R@ and GSH-P activities occurred on days 1-5@indicating that Cyclophosphamide causes lung toxicity [ ADR Type 2 ] | Cyclophosphamide-induced depression of the antioxidant defense mechanisms of the lung |
| Diethylstilbestrol | Unscheduled Dna Synthesis (Uds) | DES can potentially form phenoxyradical intermediates by a peroxidase-mediated reaction@which leads to unscheduled DNA synthesis (UDS) in Syrian hamster embryo cells. [ ADR Type 2 ] | Dependence on exogenous metabolic activation for induction of unscheduled DNA synthesis in Syrian hamster embryo cells by diethylstilbestrol and related compounds |
This panel provides information on drug category
| Toxicity | Source |
|---|