| Protein Name: | Glucose-6-phosphate 1-dehydrogenase (P11413) |
|---|---|
| Gene Name: | G6PD |
| Description: | Glucose-6-phosphate 1-dehydrogenase (EC 1 1 1 49) (G6PD) |
| PDB ID: | 1QKI |
| Protein Family: | |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Acetaminophen | Hemolysis | Patients with glucose-6-phosphate dehydrogenase deficiency who overdose with acetaminophen should be monitored for the possible development of subsequent drug-induced hemolysis [ ADR Type 3 ] | Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency |
| Cyclophosphamide | Hemolytic Anemia | Contraindicated in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency because this can precipitate hemolytic anemia [ ADR Type 3 ] | Cyclophosphamide-induced depression of the antioxidant defense mechanisms of the lung |
| Cyclophosphamide | Lung Toxicity | Significant reductions (P less than 0.005) in G6PD@ GSH-R@ and GSH-P activities occurred on days 1-5@indicating that Cyclophosphamide causes lung toxicity. [ ADR Type 2 ] | Cyclophosphamide-induced depression of the antioxidant defense mechanisms of the lung |
| Glyburide | Haemolysis | Glyburide-induced acute haemolysis in a glucose-6-phosphate dehydrogenase (G6PD) -deficient patient [ ADR Type 2 3 ] | Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM |
| Rasburicase | Hemolytic Anemia | Patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency can precipitate hemolytic anemia [ ADR Type 3 ] | Rasburicase: an innovative new treatment for hyperuricemia associated with tumor lysis syndrome |
| Teniposide | Elicit A Widespread Degradative Process Which Affects Nuclear Dna | VM-26 can elicit a widespread degradative process which affects nuclear but not mitochondrial DNA.The inhibition of genes for 18S rRNA and glucose-6-phosphate dehydrogenase were representatives. [ ADR Type 1 ] | Teniposide induces nuclear but not mitochondrial DNA degradation |
This panel provides information on drug category
| Toxicity | Source |
|---|